BSA: as a New, Efficient and Recyclable Catalyst for the Synthesis of Quinoxalines at Room Temperature
Sami Sajjadifar
Department Faculty of Chemistry, Bu-Ali Sina University, Hamedan, 6517838683, Iran
Abstract:
The reaction of boronic acid and chlorosulfonic acid in dichloromethane produced boronsulfunic acid (BSA), which was used as a novel, efficient and recyclable catalyst in presence of ethanole: water (1:1, 20 ml) for the room temperature synthesis of quinoxalines derivatives from 1,2-diamino compounds and 1,2-dicarbonyl compounds in high yield(›95%).
Quinoxaline derivatives are a very important class of nitrogen-containing compounds and have been widely used in dyes, pharmaceuticals, and electrical/photochemical materials.Quinoxaline ring moiety constitute part of the chemical structures of various antibiotics such as Echinomycin, Levomycin and Actinoleutin that are known to inhibit growth of grampositive bacteria and are active against various transplantable tumors.In recent year, the research for environmentally begin chemical processes or methodologies has received much attention, and the development of heterogeneous catalysts for fine chemical synthesis has become a major area of research. The potential for incorporation in continuous reactors and micro reactors) could lead to navel environmentally benign chemical procedures for academia and industry [1-8].
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